The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, the COVID-19 pandemic presents a huge social and health challenge worldwide. Many different risk factors are associated with disease severity, such as systemic arterial hypertension, diabetes mellitus, obesity, older age, and other co-infections. Other respiratory diseases such as chronic obstructive pulmonary disease (COPD) and smoking are common comorbidities worldwide. Previous investigations have identified among COVID-19 patients smokers and COPD patients, but recent investigations have questioned the higher risk among these populations. Nevertheless, previous reports failed to isolate smokers and COPD patients without other comorbidities. We performed a longitudinal evaluation of the disease course of smokers, former smokers, and COPD patients with COVID-19 without other comorbidities, from hospitalization to hospital discharge. Although no difference between groups was observed during hospital admission, smokers and COPD patients presented an increase in COVID-19-associated inflammatory markers during the disease course in comparison to non-smokers and former smokers. Our results demonstrated that smoking and COPD are risk factors for severe COVID-19 with possible implications for the ongoing pandemic.
【저자키워드】 COVID-19, SARS-CoV-2, Infection, smoking, chronic obstructive pulmonary disease, 【초록키워드】 coronavirus, pandemic, severe COVID-19, Hospitalization, COVID-19 pandemic, obesity, disease severity, Comorbidities, Diabetes Mellitus, Comorbidity, risk factor, COPD, Health, Respiratory disease, Patient, Older age, Hospital admission, Inflammatory marker, group, Other, disease, patients, pulmonary disease, Smokers, COVID-19 patient, smoker, acute respiratory syndrome, higher risk, no difference, hospital discharge, systemic arterial hypertension, implication, populations, Course, performed, caused, the disease, demonstrated, increase in, chronic obstructive, patients with COVID-19, 【제목키워드】 COPD, former,