The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity.
【저자키워드】 COVID-19, Inflammation, Cytokine storm, senescence, polyphenols, 【초록키워드】 coronavirus disease, pathology, ACE2, ARDS, pandemic, therapy, Pathogenesis, Respiratory failure, severe COVID-19, knowledge, SARS-COV-2 infection, severity, Cluster, morbidity and mortality, virus receptor, disease, expression, protective effect, acute respiratory distress, Coronavirus-2, marker, Evidence, high-risk population, COVID-19 patient, Clinical deterioration, World Health Organization, acute respiratory syndrome, inflammatory disorder, enzyme, individual, syndrome, SARS-CoV-2 illness, CD26, inflammatory status, Prevent, resulting, develop, characterized, promote, viral-induced, kill, acting, clinical implication, comorbid disorder, obese COVID-19 patient, 【제목키워드】 diet, elderly, Impact, profile,