Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or “cytokine storm,” increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an “eicosanoid storm,” which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial “Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids – A single-blind, randomized, placebo-controlled feasibility study” (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov : NCT04647604.
【저자키워드】 COVID-19, clinical trial, Omega-3 fatty acids, Eicosanoids, resolution of inflammation, 【초록키워드】 coronavirus disease, SARS-CoV-2, Inflammation, coronavirus, immune response, Cytokines, Respiratory failure, Trial, Study protocol, feasibility, lung, Cytokine release syndrome, Randomized, systemic inflammation, placebo-controlled, cardiovascular complications, COVID-19 patient, Trigger, arachidonic acid, acute respiratory syndrome, single-blind, Severe case, inflammatory reaction, acid, storm, local inflammation, pro-inflammatory, limit, lipid mediator, Polyunsaturated, omega-3 PUFA, reported, addition, contribute, cause, fatty, omega-3 PUFA supplementation, systemic hyperinflammatory reaction, 【제목키워드】 Resolution, rationale, acid, Stimulating,