Background COVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome. Objective In here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients Kuwait. Methods In this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients. Results COVID-19 patients with diabetes had more ICU admission than non-diabetic COVID-19 patients (20.1% vs. 16.8%, p < 0.001). Diabetic COVID-19 patients also recorded higher mortality in comparison to non-diabetic COVID-19 patients (16.7% vs. 12.1%, p < 0.001). Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications. logistic regression analysis showed that every 1 mmol/L increase in fasting blood glucose in COVID-19 patients is associated with 1.52 (95% CI: 1.34–1.72, p < 0.001) times the odds of dying from COVID-19. Conclusion Diabetes is a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases. COVID-19, Diabetes Mellitus, SARS-CoV2, inflammation, CRP, Glucose.
【저자키워드】 COVID-19, Inflammation, SARS-CoV2, Diabetes Mellitus, CRP, 【초록키워드】 Mortality, Clinical characteristics, disease severity, Comorbidities, Comorbidity, C-reactive protein, outcome, hypertension, Laboratory, Prevalence, Retrospective study, Asymptomatic, pathophysiology, management, Patient, ICU admission, death, Kuwait, understanding, complications, incidence, Glucose, COVID-19 patients, glomerular filtration rate, COVID-19 patient, Diabetic, Logistic regression analysis, worsening, single-center, laboratory investigation, objective, Result, increase in, significantly higher, contributing to, recorded, diabete, fasting blood, had more, severe respiratory symptom, 【제목키워드】 outcome, Characteristics, clinical, Kuwait, COVID-19 patient,