Since the outbreak of the 2019 novel coronavirus disease (COVID-19), the medical research community is vigorously seeking a treatment to control the infection and save the lives of severely infected patients. The main potential candidates for the control of viruses are virally targeted agents. In this short letter, we report our calculations on the inhibitors for the SARS-CoV-2 3CL protease and the spike protein for the potential treatment of COVID-19. The results show that the most potent inhibitors of the SARS-CoV-2 3CL protease include saquinavir, tadalafil, rivaroxaban, sildenafil, dasatinib, etc. Ergotamine, amphotericin b, and vancomycin are most promising to block the interaction of the SARS-CoV-2 S-protein with human ACE-2.
【저자키워드】 COVID-19, coronavirus, protease, inhibition, Spike protein, computational, 【초록키워드】 Treatment, Infection, virus, ACE-2, 2019 novel coronavirus, outbreak, Research, Community, inhibitor, disease, 3CL, Interaction, S-protein, Potential treatment, Ergotamine, candidate, severely infected patients, include, the spike protein, seeking, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, spike, 3CL, View,