Background We aimed to investigate the association of initial chest CT scan findings with status and adverse outcomes of COVID-19 (including ICU admission, mortality, and disease severity). This retrospective cohort study was performed in three hospitals in Babol, northern Iran, between February and March 2020. Cases were confirmed by real-time polymerase chain reaction (RT-PCR). Clinical and paraclinical data of the patients were collected from their medical records. CT severity score (CSS) was calculated by a senior radiologist. Disease severity was determined based on the World Health Organization criteria. Results In total, 742 patients were included, of whom 451 (60.8%) were males and 291 (39.2%) were females. The mean age was 56.59 ± 14.88 years old. Also, 523 (70.5%) were RT-PCR-positive. Ground glass opacity was directly associated with RT-PCR positivity (odds ratio [OR] = 2.07). Also, RT-PCR-positive cases had significantly a higher CSS than RT-PCR-negative cases ( p = 0.037). In patients confirmed with COVID-19, peribronchovascular distribution of lesions, number of zones involved, and CSS were associated with increased risk of ICU admission (OR = 2.93, OR = 2.10, and OR = 1.14, respectively), mortality (OR = 2.30, OR = 1.35, and OR=1.08, respectively), severe disease (OR = 2.06, OR = 1.68, and OR = 1.10, respectively), and critical disease (OR = 4.62, OR = 3.21, and OR = 1.23, respectively). Also, patients who had consolidation were at a higher risk of severe disease compared with those who did not (OR = 4.94). Conclusion Initial chest CT scan can predict COVID-19 positivity, ICU admission, mortality, and disease severity, specifically through CSS.
【저자키워드】 Coronavirus disease 2019, Clinical outcome, Computed tomography, 【초록키워드】 COVID-19, Mortality, severity, disease severity, hospital, RT-PCR, adverse outcome, Iran, clinical, male, Patient, ICU admission, age, distribution, consolidation, predict, Critical disease, association, Odds ratio, severe disease, chest CT scan, criteria, medical records, World Health Organization, retrospective cohort study, higher risk, increased risk, lesions, zone, females, polymerase chain, initial, Result, collected, significantly, involved, the patient, was performed, calculated, was determined, CSS, with COVID-19, 【제목키워드】 COVID-19, predict, chest CT scan, retrospective cohort study, initial, Can,