Morbid obese people are more likely to contract SARS-CoV-2 infection and its most severe complications, as need for mechanical ventilation. Ketogenic Diet (KD) is able to induce a fast weight loss preserving lean mass and is particularly interesting as a preventive measure in obese patients. Moreover, KD has anti-inflammatory and immune-modulating properties, which may help in preventing the cytokine storm in infected patients. Respiratory failure is actually considered a contraindication for VLCKD, a very-low calorie form of KD, but in the literature there are some data reporting beneficial effects on respiratory parameters from ketogenic and low-carbohydrate high-fat diets. KD may be helpful in reducing ventilatory requirements in respiratory patients, so it should be considered in specifically addressed clinical trials as an adjuvant therapy for obese patients infected with SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Respiratory failure, obesity, Respiratory disease, Ketogenic diet, VLCKD, low-carbohydrate high-fat diet, 【초록키워드】 clinical trial, therapy, Anti-inflammatory, mechanical ventilation, SARS-COV-2 infection, diet, respiratory, patients, weight loss, infected patients, obese, obese patients, help, ventilatory, lean mass, severe complications, Effect, reducing, induce, addressed, infected with SARS-CoV-2, ketogenic, Morbid, obese patient, respiratory parameter, the cytokine storm, 【제목키워드】 review, diet, respiratory, literature, function, narrative,