The use of nutraceutical approaches may regulate the immune system, performing a potential strategy to contain the worst outcomes of COVID-19. We reviewed the current evidence surrounding nutritional/nutraceutical approaches for the therapy in patients with COVID-19. We searched the PubMed database to report randomized controlled trials (RCTs) and observational research that used melatonin, zinc, or vitamin C supplementation as an intervention for COVID-19 treatment. To date, we found only three concluded studies that assessed zinc supplementation and melatonin therapy in patients with COVID-19, but with inconclusive data, relatively small sample size, and early termination of the trial. On the other hand, vitamin C therapy appears to reduce hyperinflammation and improve the oxygen support status of patients with COVID-19. However, a large part of this research involves pilot trials, and there are still conflicting data regarding mortality rate, mechanical ventilation, and duration of symptoms of patients with COVID-19. Melatonin, zinc, and vitamin C supplementation should be investigated further on the nutritional status-immune response, and data from ongoing trials are needed to understand these molecules as a therapy strategy in patients COVID-19.
【저자키워드】 SARS-CoV-2, clinical trial, therapy, observational study, hyperinflammation, 【초록키워드】 COVID-19, Randomized controlled trial, Treatment, Trial, melatonin, mechanical ventilation, Vitamin C, Intervention, immune system, outcome, database, Research, Patient, mortality rate, trials, RCTs, Evidence, regulate, small sample size, zinc supplementation, oxygen support, Inconclusive, IMPROVE, approach, investigated, appear, searched, reduce, duration of symptom, ongoing trial, patients with COVID-19, 【제목키워드】 COVID-19, Zinc, Vitamin, adjuvant, Potential,