Background COVID-19 has stroke Brazil harshly, deaths by COVID-19 in Brazil represent almost 13% of the total deaths by COVID-19 in the world, even though Brazilian population represents only 2.6% of the world population. Our aim in this study was to evaluate death and intubation outcomes and risk factors associated with COVID-19, and treatment options focusing on diabetes patients and the use of metformin pre-admission and during hospitalization. Methods In this Brazilian single-center study we evaluated 1170 patients hospitalized due to COVID-19. Diabetes patients (n = 188) were divided based on their use of pre-hospital and in-hospital metformin (non-met-group and met-group). Results In the total cohort most comorbidities were risk factors for orotracheal intubation and death. The use of chloroquine/hydroxychloroquine was significantly associated with increased death and intubation risk in uni- and multivariate analysis. Diabetes patients showed worst clinical feature compared with non-diabetes patients. In-hospital non-met-group had increased mortality (20.5%) compared to met-group (3.5%) (p = 0.0002) and univariable cox proportion hazard regression indicated in-hospital metformin reduced mortality (HR = 0.325, p = 0.035). Patients that used pre-hospital metformin showed lower severity parameters at hospital admission. (met-group: 2.45 ± 2.5; non-met-group: 4.25 ± 3.4). In all the groups older patients showed more severe clinical conditions and high risk of death and intubation. Conclusion Even though this is a single-center study, results from other reports have shown a similar trend, indicating that patients that used metformin during hospitalization have a better prognosis and reduced risk of death. Supplementary Information The online version contains supplementary material available at 10.1186/s13098-021-00695-8.
【저자키워드】 COVID-19, Brazil, diabetes, metformin, survival, 【초록키워드】 Treatment, Mortality, Prognosis, Hospitalization, stroke, severity, Comorbidity, intubation, risk, outcome, risk factor, Cohort, older patient, Patient, death, Hospital admission, group, patients, Analysis, chloroquine/hydroxychloroquine, high risk, In-hospital, supplementary material, reduced risk, increased mortality, single-center study, clinical condition, parameter, Result, shown, evaluate, significantly, proportion, indicated, evaluated, reduced, diabete, patients hospitalized, univariable, with COVID-19, 【제목키워드】 therapy, risk, Patient, death, In-hospital, receiving, diabete,