Background COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19-positive mothers. The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive for COVID-19 who are born to COVID-19-positive mothers. Secondary outcomes included examining laboratory abnormalities among COVID-19-positive neonates, and any depicted placental abnormalities in COVID-19-positive mothers. For this purpose, systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria. Results Final screening revealed 67 studies, from which the primary data of 1787 COVID-19 mothers were identified and had their pregnancy outcome analyzed. Only 2.8% of infants born to COVID-19-positive mothers tested positive, and this finding is identical to percentages reported in former Coronaviridae outbreaks, whereas 20% manifested with intrauterine hypoxia alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. Conclusions These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. Guidelines for proper prophylactic anticoagulation in COVID-positive mothers need to be established.
【저자키워드】 COVID-19, vertical transmission, neonatal outcome, placental infarctions, Fetal hypoxia, 【초록키워드】 pandemic, anticoagulation, hypoxia, systematic review, risk, Transmission, outcome, Prophylactic, guideline, Case report, Infant, Outbreaks, Newborn, Pregnancy, Neonates, COVID-19 infection, outbreak, morbidity, placental, Coronaviridae, mother, fatality, Evidence, Neonatal, exclusion criteria, placental insufficiency, base, positive, abnormality, Inclusion, secondary, prothrombotic, Result, tested, analyzed, reported, unlikely, was performed, laboratory abnormality, appear, searched, determine, manifested, released, percentage, with COVID-19, 【제목키워드】 hypoxia, systematic review, Transmission, Pregnancy, placental, fetal,