Background Obesity has been widely reported to be associated with the disease progression of coronavirus disease 2019 (COVID-19); however, some studies have reported different findings. We conducted a systematic review and meta-analysis to investigate the association between obesity and poor outcomes in patients with COVID-19 pneumonia. Methods A systematic review and meta-analysis of studies from the PubMed, Embase, and Web of Science databases from 1 November 2019 to 24 May 2020 was performed. Study quality was assessed, and data extraction was conducted. The meta-analysis was carried out using fixed-effects and random-effects models to calculate odds ratios (ORs) of several poor outcomes in obese and non-obese COVID-19 patients. Results Twenty-two studies ( n = 12,591 patients) were included. Pooled analysis demonstrated that body mass index (BMI) was higher in severe/critical COVID-19 patients than in mild COVID-19 patients (MD 2.48 kg/m 2 , 95% CI [2.00 to 2.96 kg/m 2 ]). Additionally, obesity in COVID-19 patients was associated with poor outcomes (OR = 1.683, 95% CI [1.408–2.011]), which comprised severe COVID-19, ICU care, invasive mechanical ventilation use, and disease progression (OR = 4.17, 95% CI [2.32–7.48]; OR = 1.57, 95% CI [1.18–2.09]; OR = 2.13, 95% CI [1.10–4.14]; OR = 1.41, 95% CI [1.26–1.58], respectively). Obesity as a risk factor was greater in younger patients (OR 3.30 vs. 1.72). However, obesity did not increase the risk of hospital mortality (OR = 0.89, 95% CI [0.32–2.51]). Conclusions As a result of a potentially critical role of obesity in determining the severity of COVID-19, it is important to collect anthropometric information for COVID-19 patients, especially the younger group. However, obesity may not be associated with hospital mortality, and efforts to understand the impact of obesity on the mortality of COVID-19 patients should be a research priority in the future.
【저자키워드】 COVID-19, Meta-analysis, obesity, poor outcomes, 【초록키워드】 coronavirus disease, Mortality, severe COVID-19, Pneumonia, hospital, systematic review, risk, progression, outcome, risk factor, database, Disease progression, body mass index, severity of COVID-19, Research, BMI, information, Critical, patients, COVID-19 patients, association, Invasive mechanical ventilation, Analysis, Odds ratio, COVID-19 patient, ICU care, Web of Science, 95% CI, obese, data extraction, effort, random-effects model, Result, greater, carried, reported, the disease, conducted, was performed, demonstrated, calculate, mild COVID-19 patient, patients with COVID-19, younger patient, 【제목키워드】 systematic review, Severity of disease,