Background The authors present an unusual, unreported oral adverse effect of COVID-19 vaccine as palatal petechiae lesions. Case presentation COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 has become a global health crisis and has caused millions of deaths worldwide. Vaccination programs have been initiated in many countries for COVID-19 prevention. The ChAdOx-nCoV-19 vaccine has been shown to provide a robust immune response in various clinical trials. It is well tolerated by recipients and has been associated with minor adverse effects. The COVISHIELD (ChAdOx-nCoV-19) vaccine developed by AstraZeneca/Oxford University is approved by the Government of India to be administered in a phased manner. We present the case of twin subjects who suffered various adverse effects after receiving the COVISHIELD vaccine; one of the twins presented with palatal petechiae lesions presumably caused by the vaccine. The lesions were self-limiting and required no treatment. Conclusion Oral lesions reported first time in our case should be correlated with similar lesions found post-COVID vaccines globally. There is a further need to ascertain a high level of scientific evidence and explore the biological plausibility underlying oral complications and COVID vaccinations.
【저자키워드】 Covishield, adverse effect, petechiae, ChAdOx-nCoV-19, 【초록키워드】 COVID-19, Treatment, Vaccine, coronavirus, COVID-19 vaccine, immune response, clinical trials, COVID-19 disease, COVID, adverse effects, Health, death, Complication, oral, university, Evidence, Vaccinations, lesion, acute respiratory syndrome, subject, lesions, recipient, biological plausibility, Administered, country, robust, shown, caused, reported, required, approved, receiving, correlated, suffered, initiated, the vaccine, Government of India, palatal, 【제목키워드】 COVID-19 vaccine,