During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, thrombosis, serine protease inhibitors, Neutrophil elastase, serine proteases, proteinase 3, cathepsin G, 【초록키워드】 Inflammation, neutrophil, Comorbidity, cardiovascular disease, management, complications, Support, biochemical, serine protease, proteolytic activity, immune defense, serine protease inhibitor, selective, chronic inflammatory disorders, immunological, indicated, activated, 【제목키워드】 cardiovascular, activity, chronic,
【저자키워드】 COVID-19, SARS-CoV-2, thrombosis, serine protease inhibitors, Neutrophil elastase, serine proteases, proteinase 3, cathepsin G, 【초록키워드】 Inflammation, neutrophil, Comorbidity, cardiovascular disease, management, complications, Support, biochemical, serine protease, proteolytic activity, immune defense, serine protease inhibitor, selective, chronic inflammatory disorders, immunological, indicated, activated, 【제목키워드】 cardiovascular, activity, chronic,