Background Coronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis of COVID-19 patients. Methods Patient information was collected from the Wuhan-Leishenshan hospital. Logistic and Cox regression analyses, Kaplan-Meier curves, and Curve fitting were used to determine the correlation between elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and AST/ALT and severity of disease/mortality. Results Logistic and Cox regression analyses and Kaplan-Meier survival curves showed that COVID-19 progression correlated with elevated levels of AST and AST/ALT. The odds ratios for elevated levels of AST and AST/ALT in patients were 0.818 (95% confidence interval [CI]: 0.274-2.441, P = 0.035) and 2.055 (95% CI: 1.269-3.327, P = 0.003), respectively; the hazard ratios were 4.195 (95% CI: 1.219-14.422, P = 0.023) and 3.348 (95% CI: 1.57-7.139, P = 0.002), respectively. The Kaplan-Meier survival curves demonstrated that patients with elevated AST and AST/ALT levels had a higher risk of developing severe COVID-19. Conclusion Elevated AST and AST/ALT levels correlated with severity of COVID-19 and mortality. Liver function tests may help clinicians in determining the prognosis of patients undergoing treatment for COVID-19.
【저자키워드】 COVID-19, Pneumonia, AST/ALT, AST - aspartate transaminase, ALT - alanine transaminase, aspartate aminotransferase/alanine aminotransferase, 【초록키워드】 Coronavirus disease 2019, pandemic, Mortality, severe COVID-19, Prognosis, severity, hospital, severity of COVID-19, Patient, Liver function, AST, correlation, COVID-19 patients, ALT, Analysis, Cox regression, Odds ratio, patient information, Liver function test, COVID-19 progression, biochemical, higher risk, clinician, 95% confidence interval, hazard ratio, Kaplan-Meier curves, help, Alanine, Aspartate transaminase, Kaplan-Meier survival curve, Result, elevated, was collected, were used, determine, demonstrated, correlated, prognosis of patient, analyses, Curve, treatment for COVID-19, 【제목키워드】 Wuhan, Potential,