The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. This study was designed to estimate whether liver dysfunction and abnormal ILs could predict the severity of COVID-19. This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. This study may give more exact information to clinicians about the prognosis of patients with COVID-19. In addition, this correlational study between liver disorder and ILs may provide a new vision to diagnosis and treatment in patients.
【저자키워드】 COVID-19, Prognosis, IL-6, Liver injury, IL-2R, 【초록키워드】 Treatment, SARS-CoV-2, coronavirus, pandemic, Epidemiology, interleukin-6, Diagnosis, novel coronavirus disease, Spread, Characteristics, severity of COVID-19, clinical, Patient, Liver function, receptor, Severe patient, information, liver, patients, predict, liver dysfunction, association, acute respiratory syndrome, clinician, disorder, feature, caused, addition, the WHO, prognosis of patient, infected with SARS-CoV-2, patients with COVID-19, with COVID-19, 【제목키워드】 Interleukins, interleukin-2, Level,