Background: The viral shedding time (VST) of SARS-CoV-2 mainly determines its transmission and duration of infectiousness. However, it was heterogeneous in the existing studies. Here, we performed a meta-analysis to comprehensively summarize the VST of SARS-CoV-2. Methods: We searched PubMed, Web of Science, MedRxiv, BioRxiv, CNKI, CSTJ, and Wanfang up to October 25, 2020, for studies that reported VSTs of SARS-CoV-2. Pooled estimates and 95% CIs for the VSTs were calculated using log-transformed data. The VSTs in SARS-CoV-2 infections based on different demographic and clinical characteristics, treatments and specimens were stratified by subgroup analysis. Results: A total of 35 studies involving 3,385 participants met the inclusion criteria. The pooled mean VST was 16.8 days (95% CI: 14.8–19.4, I 2 = 99.56%) in SARS-CoV-2 infections. The VST was significantly longer in symptomatic infections (19.7 days, 95% CI: 17.2–22.7, I 2 = 99.34%) than in asymptomatic infections (10.9 days, 95% CI: 8.3–14.3, I 2 = 98.89%) ( P < 0.05). The VST was 23.2 days (95% CI: 19.0–28.4, I 2 = 99.24%) in adults, which was significantly longer than that in children (9.9 days, 95% CI: 8.1–12.2, I 2 = 85.74%) ( P < 0.05). The VST was significantly longer in persons with chronic diseases (24.2 days, 95% CI: 19.2–30.2, I 2 = 84.07%) than in those without chronic diseases (11.5 days, 95% CI: 5.3–25.0, I 2 = 82.11%) ( P < 0.05). Persons receiving corticosteroid treatment (28.3 days, 95% CI: 25.6–31.2, I 2 = 0.00%) had a longer VST than those without corticosteroid treatment (16.2 days, 95% CI: 11.5–22.5, I 2 = 92.27%) ( P = 0.06). The VST was significantly longer in stool specimens (30.3 days, 95% CI: 23.1–39.2, I 2 = 92.09%) than in respiratory tract specimens (17.5 days, 95% CI: 14.9–20.6, I 2 = 99.67%) ( P < 0.05). Conclusions: A longer VST was found in symptomatic infections, infected adults, persons with chronic diseases, and stool specimens.
【저자키워드】 COVID-19, Meta-analysis, systematic review, SARS- CoV-2, viral shedding time, 【초록키워드】 Treatment, SARS-CoV-2, Clinical characteristics, SARS-COV-2 infection, children, viral shedding, Transmission, chronic disease, Adults, Stool, asymptomatic infection, estimate, specimens, SARS-CoV-2 infections, symptomatic infection, Chronic diseases, Web of Science, 95% CI, inclusion criteria, specimen, medRxiv, participant, subgroup analysis, heterogeneous, bioRxiv, CNKI, symptomatic infections, corticosteroid treatment, performed, significantly, reported, receiving, calculated, searched, determine, stratified, log-transformed, Person, respiratory tract specimen, VST, 【제목키워드】 SARS-CoV-2, review, shedding, time,