The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which is causing the coronavirus disease-2019 (COVID-19) pandemic, poses a global health threat. However, it is easy to confuse COVID-19 with seasonal influenza in preliminary clinical diagnosis. In this study, the differences between influenza and COVID-19 in epidemiological features, clinical manifestations, comorbidities and pathogen biology were comprehensively compared and analyzed. SARS-CoV-2 causes a higher proportion of pneumonia (90.67 vs. 17.07%) and acute respiratory distress syndrome (12.00 vs. 0%) than influenza A virus. The proportion of leukopenia for influenza patients was 31.71% compared with 12.00% for COVID-19 patients ( P = 0.0096). The creatinine and creatine kinase were significantly elevated when there were COVID-19 patients. The basic reproductive number (R 0 ) for SARS-CoV-2 is 2.38 compared with 1.28 for seasonal influenza A virus. The mutation rate of SARS-CoV-2 ranges from 1.12 × 10 −3 to 6.25 × 10 −3 , while seasonal influenza virus has a lower evolutionary rate (0.60-2.00 × 10 −6 ). Overall, this study compared the clinical features and outcomes of medically attended COVID-19 and influenza patients. In addition, the S477N and N439K mutations on spike may affect the affinity with receptor ACE2. This study will contribute to COVID-19 control and epidemic surveillance in the future.
【저자키워드】 COVID-19, Influenza, Epidemic, comparison, adaptive mutation, 【초록키워드】 SARS-CoV-2, coronavirus, pandemic, Mutation, Pneumonia, influenza A virus, Comorbidity, outcome, virus, clinical manifestations, Health, Features, pathogen, Surveillance, Patient, epidemiological, Clinical diagnosis, patients, N439K, clinical feature, COVID-19 patients, acute respiratory distress, creatinine, Evolutionary rate, COVID-19 patient, basic reproductive number, Seasonal influenza, acute respiratory syndrome, syndrome, leukopenia, receptor ACE2, S477N, Affect, significantly, proportion, addition, elevated, contribute, cause, compared and analyzed, 【제목키워드】 Population, clinical, respiratory, season,