ABSTRACT The coronavirus disease 19 (COVID-19) is responsible for the current worldwide pandemic. Treatment and prophylaxis are still under investigation. Convalescent plasma therapy could be an alternative. We report a case of a 41-year-old patient, at 28 weeks of gestation, was hospitalized with COVID-19. On the 10 th day after onset of symptoms, the clinical picture worsened, and she required high-flow oxygen therapy (30L/minute), with 92% oxygen saturation, and chest X-ray showing mild bilateral opacities at lung bases. Blood tests showed D-dimer 1,004ng/mL, C-reactive protein 81mg/L, pro-calcitonin 0.05ng/mL and interleukine-6 42.9pg/mL. The therapy chosen was Tazocin ® 12g/day, vancomycin 2g/day, and methylprednisolone 40mg/day. In addition, convalescent plasma therapy was administered (275mL) uneventfully, including SARS-CoV-2 antibodies and neutralizing antibodies >1:160. The patient had a fast recovery. The early administration of convalescent plasma, with high titers of neutralizing antibodies, may be an alternative option for severe COVID-19 during pregnancy, until further studies demonstrate an efficient and safe treatment or prophylaxis.
【저자키워드】 COVID-19, convalescent plasma, Coronavirus infections, Pregnancy, antibodies, neutralizing, plasma, Pregnancy complications, infectious, 【초록키워드】 Methylprednisolone, Treatment, coronavirus disease, neutralizing antibody, therapy, Hospitalized, severe COVID-19, Neutralizing antibodies, lung, C-reactive protein, D-dimer, Prophylaxis, oxygen saturation, Convalescent plasma therapy, SARS-CoV-2 antibody, clinical picture, Patient, Mild, chest X-ray, blood test, Safe, gestation, worldwide pandemic, early administration, bases, high-flow oxygen therapy, Administered, pro-calcitonin, responsible, addition, required, onset of symptoms, with COVID-19, worsened, 【제목키워드】 Case report, Pregnant woman, Convalescent plasma therapy, management,