Simple Summary Infections with COVID-19 in neutropenic cancer patients are related to poor outcomes. A G-CSF treatment used in neutropenic cancer with SARS-CoV-2 infections is related to a higher rate of respiratory failure according to progressive and growing evidence. In this small retrospective non-randomized study, we found an association between G-CSF treatment and the parameters predisposing for worse infections with COVID-19 and neutropenia compared with patients not treated with G-CSF. We also found that the number of days on G-CSF treatment was related to a higher risk of mortality in a multivariable analysis among patients treated with G-CSF. Abstract Background: Approximately 15% of patients infected by SARS-CoV-2 develop a distress syndrome secondary to a host hyperinflammatory response induced by a cytokine storm. Myelosuppression is associated with a higher risk of infections and mortality. There are data to support methods of management for neutropenia and COVID-19. We present a multicenter experience during the first COVID-19 outbreak in neutropenic cancer patients infected by SARS-CoV-2. Methods: Clinical retrospective data were collected from neutropenic cancer patients with COVID-19. Comorbidities, tumor type, stage, treatment, neutropenia severity, G-CSF, COVID-19 parameters, and mortality were analyzed. A bivariate analysis of the impact on mortality was carried out. Additionally, we performed a multivariable logistic regression to predict respiratory failure and death. Results: Among the 943 cancer patients screened, 83 patients (11.3%) simultaneously had neutropenia and an infection with COVID-19. The lungs (26%) and breasts (22%) were the primary locations affected, and most patients had advanced disease (67%). In the logistic model, as adjusted covariates, sex, age, treatment (palliative vs. curative), tumor type, and the lowest level of neutrophils were used. A significant effect was obtained for the number of days of G-CSF treatment (OR = 1.4, 95% CI [1,1,03,92], p -value = 0.01). Conclusions: Our findings suggest that a prolonged G-CSF treatment could be disadvantageous for these cancer patients with infections by COVID-19, with a higher probability of worse outcome.
【저자키워드】 COVID-19, Respiratory failure, neutropenia, G-CSF treatment, 【초록키워드】 Treatment, SARS-CoV-2, Cytokine storm, Mortality, SARS-COV-2 infection, severity, Cancer, neutrophil, Infection, lung, Sex, outcome, outcomes, Probability, COVID-19 outbreak, clinical, management, Patient, death, age, multicenter, covariates, parameters, predict, association, Evidence, retrospective, Analysis, distress, cancer patient, Support, Logistic, higher risk, 95% CI, significant effect, multivariable logistic regression, syndrome, multivariable analysis, P -value, G-CSF, advanced disease, parameter, simple, Host, Hyperinflammatory, lowest, analyzed, performed, affected, collected, develop, carried, screened, treated, adjusted, were used, non-randomized, was obtained, curative, infection with COVID-19, patients treated, was related, with COVID-19, 【제목키워드】 Comparative, Factor, Stimulating,