The risk and potential consequences of mother-to-child transmission of severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) during pregnancy are still a matter of debate. We studied the impact of SARS-CoV-2 infection on 56 complete households, including 27 newborns whose mothers were pregnant when exposed to the virus. Two PCR-confirmed perinatal SARS-CoV-2 transmissions with mild symptoms in affected neonates were recorded. In addition, we observed a severe eye malformation (unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy) associated with maternal SARS-CoV-2 infection in weeks 5 and 6 of embryonic development. This embryopathy could not be explained by other infectious agents, genetic factors, drug use, or maternal disease during pregnancy. Eight other women with a history of SARS-CoV-2 infection prior to gestational week 12, however, delivered healthy infants. Conclusion : The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women. Trial registration number: NCT04741412. Date of registration: November 18, 2020 What is Known: •Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases. What is New: •In a study of complete households with documented SARS-CoV-2 infection, including a cohort of pregnant women, we observed perinatal coronavirus transmission at a higher frequency than expected. •We also describe a newborn boy with an eye malformation reminiscent of rubella embryopathy but associated with early gestation SARS-CoV-2 infection of his mother. •A coronavirus-related embryopathy, reported here for the first time, is a finding that requires further investigation. Supplementary information The online version contains supplementary material available at 10.1007/s00431-021-04221-w.
【저자키워드】 coronavirus, Case report, malformation, Materno-fetal transmission, Embryopathy, 【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, Genetic, risk, Transmission, virus, pregnant women, Infants, Cohort, Newborn, SARS-CoV-2 transmission, Pregnancy, Neonate, COVID-19 vaccination, Factors, women, information, disease, mother, Frequency, pregnant, infectious agents, Support, Mild symptom, supplementary material, PCR-confirmed, researcher, Effect, Complete, recommendation, repeated, consequence, Occurrence, affected, healthy, reported, addition, explained, demonstrated, expected, stimulate, embryonic, were recorded, Date, early gestation, optic nerve hypoplasia, 【제목키워드】 SARS-COV-2 infection, Maternal,