Introduction The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. Methods This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. Ethics and dissemination The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.
【저자키워드】 COVID-19, SARS-CoV-2, Quality of life, Patient-reported outcome measures, Qualidade de vida, Medidas de resultados relatados pelo paciente, 【초록키워드】 Brazil, randomized clinical trial, Anxiety, Depression, Study protocol, Hospitalization, SARS-COV-2 infection, Ethics, Symptom, outcome, prospective cohort study, activity, COVID-19 treatment, Research Ethics, outcomes, Health, Characteristics, Impact, Dyspnea, scale, multicenter, dissemination, utility, association, Functional status, demographic characteristics, life, Visual, Medical Research Council, ventilatory support, posttraumatic stress disorder, Posttraumatic Stress, Cardiovascular events, Factor, Primary outcome, all-cause mortality, daily living, ethics committee, Modified Medical Research Council Dyspnea Scale, Research Ethics Committee, disorder, conferences, acute illness, survivor, variable, Effect, Daily, FIVE, physical, secondary, performed, caused, include, approved, functional, peer-reviewed, Generalized, Instrumental, premorbid, variables, 【제목키워드】 Hospitalization, outcome, prospective cohort study, Quality, life, Coalition,