In only a few months after initial discovery in Wuhan, China, SARS-CoV-2 and the associated coronavirus disease 2019 (COVID-19) have become a global pandemic causing significant mortality and morbidity and implementation of strict isolation measures. In the absence of vaccines and effective therapeutics, reliable serological testing must be a key element of public health policy to control further spread of the disease and gradually remove quarantine measures. Serological diagnostic tests are being increasingly used to provide a broader understanding of COVID-19 incidence and to assess immunity status in the population. However, there are discrepancies between claimed and actual performance data for serological diagnostic tests on the market. In this study, we conducted a review of independent studies evaluating the performance of SARS-CoV-2 serological tests. We found significant variability in the accuracy of marketed tests and highlight several lab-based and point-of-care rapid serological tests with high levels of performance. The findings of this review highlight the need for ongoing independent evaluations of commercialized COVID-19 diagnostic tests.
【저자키워드】 COVID-19, SARS-CoV-2, performance, serological diagnostic test, 【초록키워드】 coronavirus disease, public health, Vaccine, Mortality, Immunity, quarantine, diagnostic test, global pandemic, Spread, point-of-care, Measures, Serological testing, Accuracy, diagnostic tests, implementation, morbidity, Isolation, serological, COVID-19 incidence, Variability, discrepancy, effective, rapid serological test, independent, highlight, Wuhan, China, initial, the disease, conducted, absence, increasingly, claimed, 【제목키워드】 well,