It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.
【저자키워드】 COVID-19, Inflammation, Biomarker, Respiratory function, GDF-15, 【초록키워드】 coronavirus disease, Stratification, Biomarkers, severity, interleukin-6, C-reactive protein, ferritin, oxidative stress, lymphopenia, Patient, D-dimer level, Support, healthy control, COVID-19 case, circulating, receiver operating characteristics, pathological condition, pulmonary impairment, laboratory parameter, analysed, correlated, upregulated, patients with COVID-19, 【제목키워드】 novel, respiratory, differentiation, function, Factor,