Patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure within a short period during the clinical course. It is essential to predict respiratory deterioration in the short term. We investigated the use of inflammatory markers to predict respiratory distress within three days from their analysis in COVID-19 patients. This retrospective observational study included 81 patients admitted with COVID-19. Patients were divided into two groups according to whether the maximum fraction of inspired oxygen (FiO 2 ) for three days from the blood marker measurements was ≥0.4 (high FiO 2 group; HFG) or <0.4 (low FiO 2 group; LFG). Interleukin-6 (IL-6), C-reactive protein (CRP), lactate dehydrogenase (LDH), white blood cell, D-dimer, and creatinine levels were compared between the two groups. The levels of all markers were significantly higher in HFG patients. Areas under the receiver operating characteristic curve of IL-6, CRP, and LDH had high values of 0.85, 0.82, and 0.81, respectively. The odds ratio of IL-6 which was crude and adjusted for dexamethasone administration initiated before laboratory measurement, showed the high value of 29.1 (5.6–295.6) and 53.9 (4.5–3242.8), respectively. IL-6 can be used as a reliable marker for predicting respiratory illness within three days after assessment.
【저자키워드】 Respiratory failure, interleukin-6, novel coronavirus disease, Inflammatory marker, 【초록키워드】 COVID-19, Dexamethasone, coronavirus disease, IL-6, severe respiratory failure, LDH, Respiratory illness, C-reactive protein, CRP, D-dimer, oxygen, lactate dehydrogenase, Laboratory, Clinical course, Deterioration, White blood cell, Patient, characteristic, patients, predict, COVID-19 patients, Blood, marker, retrospective, administration, creatinine, Analysis, distress, Odds ratio, two groups, fraction, develop, investigated, can be used, adjusted, significantly higher, initiated, two group, Area, with COVID-19, 【제목키워드】 COVID-19, respiratory, failure, value,