As the coronavirus disease 2019 (COVID-19) pandemic grows throughout the world, it is imperative that all approaches to ameliorating its effects be investigated, including repurposing drugs that show promise in other diseases. We have been investigating an approach to multiple disorders that involves recruiting the innate immune system to aid the body’s healing and regenerative mechanism(s). In the case of West Nile Virus encephalitis and potentially COVID-19, the proposed intervention to stimulate the innate immune system may give the adaptive immune response the necessary time to develop, finish clearing the virus, and provide future immunity. Furthermore, we have found that GM-CSF-induced recruitment of the innate immune system is also able to reverse brain pathology, neuroinflammation and cognitive deficits in mouse models of Alzheimer’s disease and Down syndrome, as well as improving cognition in normal aging and in human patients with cognitive deficits due to chemotherapy, both of which exhibit neuroinflammation. Others have shown that GM-CSF is an effective treatment for both bacterial and viral pneumonias, and their associated inflammation, in animals and that it has successfully treated pneumonia-associated Acute Respiratory Distress Syndrome in humans. These and other data strongly suggest that GM-CSF may be an effective treatment for many viral infections, including COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, acute respiratory distress syndrome, Neuroinflammation, Alzheimer’s disease, West Nile Virus, granulocyte-macrophage colony-stimulating factor, 【초록키워드】 Treatment, coronavirus disease, pathology, pandemic, Immunity, GM-CSF, Intervention, drug, virus, viral infections, Brain, Encephalitis, Alzheimer’s disease, innate immune system, Chemotherapy, humans, Patient, Adaptive immune response, respiratory, recruitment, mouse model, Other, regenerative, Down syndrome, Bacterial, cognitive, other diseases, West, disorder, viral pneumonias, Effect, approach, effective, shown, develop, approach, investigated, treated, imperative, stimulate, Nile, 【제목키워드】 GM-CSF, Encephalitis, innate immune system, Viral diseases, West, Nile,