In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identified as immunogenic is the CD8 + T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*24:02. The HLA-A*24:02 allele is found in the majority of Japanese individuals and several indigenous populations in Asia, Oceania, and the Americas. In combination with histories of common cold infections, HLA-A*24:02 may affect their protection from COVID-19.
【저자키워드】 COVID-19, peptide, T cell, HLA, Japanese, epitope, MHC, VYIGDPAQL, SPRWYFYYL, 【초록키워드】 coronavirus, CD8, Population, Asia, Protein, infections, MHC class I, immune memory, common cold, HLA-A*24:02, Combination, COVID-19 patient, individual, common cold coronavirus, immunogenic, allele, Specificities, Americas, Oceania, Affect, majority, recognize, addressed, 【제목키워드】 Protein, individual, common cold coronavirus, immunogenic, MOST, recognize,