Background: Data on the prevalence of bacterial co-infections among COVID-19 patients are limited, especially in our country, Indonesia. We aimed to assess the rate of bacterial co-infections in hospitalized COVID-19 patients and report the most common microorganisms involved and the antibiotic use in these patients. Methods: This study is a retrospective cohort study,among COVID-19 adult patients admitted to Universitas Airlangga Hospital Surabaya from 14 March-30 September 2020. The bacterial infection is defined based on clinical assessment, laboratory parameters, and microbiology results. Results: A total of 218 patients with moderate to critical illness and confirmed COVID-19 were included in this study. Bacterial infection was confirmed in 43 patients (19.7%). COVID-19 patients with bacterial infections had longer hospital length of stay (17.6 6.62 vs 13.317.12), a higher proportion of respiratory failure, intensive care treatment, and ventilator use. COVID-19 patients with bacterial infection had a worse prognosis than those without bacterial infection (p<0.04). The empirical antibiotic was given to 75.2% of the patients. Gram-negative bacteria were commonly found as causative agents in this study (n = 39; 70.37%). Conclusion: COVID-19 patients with bacterial infection have a longer length of stay and worse outcomes. Healthcare-associated infections during intensive care treatment for COVID-19 patients must be carefully prevented.
【저자키워드】 COVID-19, SARS-CoV-2, Antibiotics, Bacterial infection, 【초록키워드】 Respiratory failure, hospital, Infection, Prevalence, outcomes, Patient, Indonesia, Laboratory parameters, Critical, bacterial co-infection, antibiotic use, patients, hospitalized COVID-19 patient, microorganism, antibiotic, COVID-19 patient, Gram-negative bacteria, ventilator, intensive care treatment, worse prognosis, retrospective cohort, country, defined, involved, proportion, prevented, COVID-19 adult patient, patients with moderate, 【제목키워드】 hospital, Critically ill, clinical impact, moderate, bacterial co-infection, COVID-19 patient,