Aim: This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine wards. Materials & methods: The authors retrospectively reviewed 113 hospitalized patients with COVID-19. They assessed antibody response against five SARS-CoV-2 epitopes at 6–14 days post symptom onset in these patients. Results: Patients with ICU admissions had decreased anti-nucleocapsid immunoglobulin (Ig)M and increased anti-spike IgG compared with patients not requiring the ICU. IgG levels were positively correlated with length of stay. Conclusion: Higher levels of IgG against the spike protein correlate with COVID-19 disease severity and length of stay in hospitalized patients. This adds to the knowledge of biochemical response to clinical disease and may help predict ICU needs. Plain language summary This study analyzed blood samples in patients hospitalized with COVID-19 at 6–14 days after their initial symptom onset. Those who needed care in the intensive care unit had lower levels of an early antibody (IgM) to a protein inside the virus and higher levels of a later antibody (IgG) to the spike protein on the outer viral membrane. Higher IgG levels were also associated with longer hospital stays.
【저자키워드】 COVID-19, immunology, SARS-CoV-2, Antibody Response, Infectious disease, ICU, Spike protein, 【초록키워드】 IgG, IgM, intensive care, antibody, knowledge, disease severity, hospital, hospitalized patients, virus, Protein, Immunoglobulin, anti-Spike IgG, Patient, ICU admission, Care, patients, predict, humoral, initial symptom, symptom onset, biochemical, viral membrane, blood sample, help, material, clinical disease, FIVE, analyzed, investigated, hospitalized patient, the spike protein, antibody response against, IgG level, patients hospitalized, positively correlated, SARS-CoV-2 epitope, with COVID-19, 【제목키워드】 IgG, IgM, Depression, intensive care, SARS-COV-2 infection, correlated,