Aim: Low levels of immune-related micronutrients have been identified in β-thalassemia samples. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in β-thalassemia, which is important during the COVID-19 pandemic. Materials & Methods: Searches of PUBMED and EMBASE were conducted to identify the level and supplementation of micronutrients in β-thalassemia, published from 2001–May 2020. Results: The review found six observational and five interventional studies supporting the importance of supplementing vitamins and minerals among patients with β-thalassemia. Conclusion: Supplementation of immune-related vitamins and minerals might bring benefits to the immune system, especially in reducing oxidative stress in β-thalassemia. Lay abstract Nutrition is important for the human body, including the immune system. During COVID-19, maintaining immunity is crucial to prevent transmission, because vaccines remain under development and definitive therapy is under clinical trial. In β-thalassemia, for which immune-related vitamins and minerals are inadequate, supplementation is important, not only to boost the immune system during this outbreak but also to maintain other body functions.
【저자키워드】 SARS-CoV-2, Zinc, Immunity, cholecalciferol, Selenium, ascorbic acid, good health and well being, tocopherol, 【초록키워드】 COVID-19, Vaccine, clinical trial, therapy, Micronutrient, Pathogenesis, COVID-19 pandemic, nutrition, Transmission, immune system, oxidative stress, outbreak, Patient, Vitamin, boost, Abstract, functions, material, Alter, FIVE, Prevent, benefit, mineral, identify, the disease, conducted, reducing, maintain, contributing to, β-thalassemia, 【제목키워드】 COVID-19 pandemic, Vitamin, β-thalassemia,