Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
【저자키워드】 SARS-CoV-2, HIV, Neuroinflammation, flavivirus, microglia, brain aging, neurotropic virus, human herpes virus, 【초록키워드】 viral infection, Influenza, virus, immune, Brain, Health, Central nervous system, disease, Evidence, Inflammatory, Immune cell, physiological, deficiency, functions, herpes viruses, Affect, neurotropic, virus, contribute, induce, interfere, accelerate, accelerated, remodeling processes, 【제목키워드】 aging, influence,