Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in virtually all tissues; they have a potent self-renewal capacity and can differentiate into multiple cell types. They also affect the ambient tissue by the paracrine secretion of numerous factors in vivo, including the induction of other stem cells’ differentiation. In vitro, the culture media supernatant is named secretome and contains soluble molecules and extracellular vesicles that retain potent biological function in tissue regeneration. MSCs are considered safe for human treatment; their use does not involve ethical issues, as embryonic stem cells do not require genetic manipulation as induced pluripotent stem cells, and after intravenous injection, they are mainly found in the lugs. Therefore, these cells are currently being tested in various preclinical and clinical trials for several diseases, including COVID-19. Several affected COVID-19 patients develop induced acute respiratory distress syndrome (ARDS) associated with an uncontrolled inflammatory response. This condition causes extensive damage to the lungs and may leave serious post-COVID-19 sequelae. As the disease may cause systemic alterations, such as thromboembolism and compromised renal and cardiac function, the intravenous injection of MSCs may be a therapeutic alternative against multiple pathological manifestations. In this work, we reviewed the literature about MSCs biology, focusing on their function in pulmonary regeneration and their use in COVID-19 treatment.
【저자키워드】 COVID-19, Inflammation, Cell therapy, Mesenchymal stem cells, tissue regeneration, 【초록키워드】 Treatment, ARDS, clinical trial, Diseases, lung, MSCs, pluripotent stem cells, therapeutic, Thromboembolism, Manifestations, extracellular vesicle, in vivo, cardiac function, mesenchymal stem cell, acute respiratory distress, Inflammatory response, MSC, COVID-19 patient, Safe, stem cell, cell types, culture media, Secretome, Factor, Intravenous injection, tissue, secretion, syndrome, renal, supernatant, ambient, genetic manipulation, Affect, tested, affected, develop, the disease, cause, embryonic, these cell, alterations, paracrine, 【제목키워드】 Future, STEM,