The article describes the rationale for inhibition of the renin-angiotensin system (RAS) pathways as specific targets in patients infected by SARS-CoV-2 in order to prevent positive feedback-loop mechanisms. Based purely on experimental studies in which RAS pathway inhibitors were administered in vivo to humans/rodents, a reasonable hypothesis of using inhibitors that block both ACE and ACE2 zinc metalloproteases and their downstream pathways in COVID-19 patients will be proposed. In particular, metal (zinc) chelators and renin inhibitors may work alone or in combination to inhibit the positive feedback loops (initially triggered by SARS-CoV-2 and subsequently sustained by hypoxia independently on viral trigger) as both arms of renin-angiotensin system are upregulated, leading to critical, advanced and untreatable stages of the disease.
【저자키워드】 Asthma, hypoxia, severe acute respiratory syndrome coronavirus-2, hypertension, eosinophil, renin-angiotensin system, Mas receptor, Lung fibrosis, IL-10, cardiac dysfunction, 【초록키워드】 SARS-CoV-2, ACE2, RAS, Patient, pathway, target, mechanisms, in vivo, inhibitor, Critical, Combination, Hypothesis, ACE, COVID-19 patient, Stage, positive, downstream, positive feedback loop, Administered, Arm, Prevent, inhibit, the disease, upregulated, triggered, sustained, 【제목키워드】 COVID-19, rationale, System,