Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (COVID-19). The virus invades human cells through the angiotensin-converting enzyme 2 (ACE2) receptor-driven pathway, primarily targeting the human respiratory tract. However, emerging reports of neurological manifestations demonstrate the neuroinvasive potential of SARS-CoV-2. This review highlights the possible routes by which SARS-CoV-2 may invade the central nervous system (CNS) and provides insight into recent case reports of COVID-19-associated neurological disorders, namely ischaemic stroke, encephalitis, encephalopathy, epilepsy, neurodegenerative diseases, and inflammatory-mediated neurological disorders. We hypothesize that SARS-CoV-2 neuroinvasion, neuroinflammation, and blood-brain barrier (BBB) dysfunction may be implicated in the development of the observed disorders; however, further research is critical to understand the detailed mechanisms and pathway of infectivity behind CNS pathogenesis.
【저자키워드】 COVID-19, SARS-CoV-2, blood-brain barrier, Neurological disorders, CNS, cerebrovascular, 【초록키워드】 coronavirus disease, ACE2, coronavirus, Diseases, Pathogenesis, epilepsy, virus, angiotensin-converting enzyme 2, Encephalitis, Case report, global pandemic, Research, Neuroinflammation, pathway, Encephalopathy, Central nervous system, Critical, mechanism, SARS-CoV-2 neuroinvasion, Neuroinvasive, dysfunction, ischaemic stroke, acute respiratory syndrome, human respiratory tract, human cell, neurological manifestation, highlight, provide, implicated, neurodegenerative, 【제목키워드】 barrier, route, Potential, Relevance,