The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses , only eight years after the emergence of another zoonotic betacoronavirus , the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I ( HLA-A-24 -like) and II ( HLA-DPB1 -like), and innate immune response ( PTPN4, MAGOHB ), and in cilia coating the respiratory tract ( DNAH7 ). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses , although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.
【저자키워드】 coronavirus, zoonosis, immune response genes, Old World camels, in-solution hybridization capture, 【초록키워드】 SARS-CoV-2, innate immune response, adaptive, SARS-CoV-2 pandemic, Genetic, MERS-CoV, Betacoronavirus, Testing, viral replication, humans, zoonotic, pathway, respiratory tract, disease, function, association, candidate gene, Middle East, human infections, respiratory syndrome coronavirus, MERS-CoV infection, HLA-DPB1, while, DNAH7, Host, required, eight, MAGOHB, PTPN4, United Arab Emirate, 【제목키워드】 MERS-CoV, Innate, Dromedary,