Viral pathogens often exploit host cell regulatory and signaling pathways to ensure an optimal environment for growth and survival. Several studies have suggested that 5′-adenosine monophosphate-activated protein kinase (AMPK), an intracellular serine/threonine kinase, plays a significant role in the modulation of infection. Traditionally, AMPK is a key energy regulator of cell growth and proliferation, host autophagy, stress responses, metabolic reprogramming, mitochondrial homeostasis, fatty acid β-oxidation and host immune function. In this review, we highlight the modulation of host AMPK by various viruses under physiological conditions. These intracellular pathogens trigger metabolic changes altering AMPK signaling activity that then facilitates or inhibits viral replication. Considering the COVID-19 pandemic, understanding the regulation of AMPK signaling following infection can shed light on the development of more effective therapeutic strategies against viral infectious diseases.
【저자키워드】 COVID-19, Apoptosis, virus, autophagy, AMPK, lipid metabolism, fatty acid metabolism, catabolic process, anabolic processes, mitochondrial homeostasis, 【초록키워드】 Stress, COVID-19 pandemic, Infection, Regulatory, Protein, survival, pathogen, viral replication, immune function, signaling pathway, change, therapeutic strategy, homeostasis, Signaling, proliferation, mitochondrial, host cell, Regulation, modulation, growth, physiological conditions, viral infectious diseases, Host, responses, effective, Cell, highlight, virus, inhibit, facilitate, suggested, fatty, 【제목키워드】 role,