Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) codon usage, as shown by the polyprotein coding sequence, shows better translation potential in the human host when compared with human coronavirus OC43 (HCoV-OC43) codon usage. Such translational advantage might facilitate SARS-CoV-2 replication, immunogenicity, and pathogenicity, thus also accounting for the less harmful character of HCoV-OC43 infection.
All Keywords
【저자키워드】 SARS-CoV-2, HCoV-OC43, codon usage, viral replication fitness, 【초록키워드】 coronavirus, translation, Infection, human coronavirus OC43, pathogenicity, SARS-CoV-2 replication, acute respiratory syndrome, human host, coding sequence, polyprotein, shown, facilitate, less, translational, 【제목키워드】 coronavirus 2, fitness, respiratory, Usage, codon,
【저자키워드】 SARS-CoV-2, HCoV-OC43, codon usage, viral replication fitness, 【초록키워드】 coronavirus, translation, Infection, human coronavirus OC43, pathogenicity, SARS-CoV-2 replication, acute respiratory syndrome, human host, coding sequence, polyprotein, shown, facilitate, less, translational, 【제목키워드】 coronavirus 2, fitness, respiratory, Usage, codon,