The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we discuss the therapeutic potential of probiotics as an alternative medicine to prevent or alleviate severe COVID-19 outcome.
【저자키워드】 SARS-CoV-2, severe COVID-19, gut-lung axis, Enteric infection, intestinal dysbiosis, 【초록키워드】 COVID-19, coronavirus disease, coronavirus, immune response, COVID-19 severity, immunopathology, outcome, global pandemic, Health, severity of COVID-19, morbidity and mortality, COVID-19 patients, association, Evidence, Frequency, Gut, digestive tract, acute respiratory syndrome, therapeutic potential, syndrome, microenvironment, Prevent, intestinal, IMPROVE, caused, alleviate, 【제목키워드】 COVID-19, response, Gastrointestinal, axis,