Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
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【저자키워드】 SARS-CoV-2, Tetherin/BST2, Zn binding, molecular dynamics computer simulation, zinc finger, orf7a and orf8 proteins, 【초록키워드】 Zinc, feasibility, Proteins, Antigen, Protein, ORF8, binding, ORF7a, cellular, Interaction, Hypothesis, host cell, maturation, virion, lack, involved, activated, expressed,
【저자키워드】 SARS-CoV-2, Tetherin/BST2, Zn binding, molecular dynamics computer simulation, zinc finger, orf7a and orf8 proteins, 【초록키워드】 Zinc, feasibility, Proteins, Antigen, Protein, ORF8, binding, ORF7a, cellular, Interaction, Hypothesis, host cell, maturation, virion, lack, involved, activated, expressed,