The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, spike, drugs, Polymorphisms, ACE-2, 【초록키워드】 Vaccine, Mortality, drug design, Genetic, SARS-CoV-2 virus, virus, respiratory diseases, outbreak, morbidity, information, disease, predict, therapeutic strategy, Analysis, close contact, infected patients, residue, effort, infection risks, viral burden, approach, effective, Course, develop, caused, involved, addition, the disease, generate, reducing, increase in, affecting, polymorphic variant, 【제목키워드】 drug, Against,