Summary The current severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. In this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with SARS‐CoV‐2, from the initial discovery of the virus in December 2019 through to October 2020. We systematically searched four databases (Scopus, PubMed, Science Direct and Web of Science). The following data were extracted from the included studies: type of infection (natural or experimental), age, sample numbers, dose, route of inoculation, viral replication, detection method, clinical symptoms and transmission. Fifty‐four studies were included, of which 34 were conducted on animal reservoirs (naturally or experimentally infected), and 20 involved models for testing vaccines and therapeutics. Our search revealed that Rousettus aegyptiacus (fruit bats), pangolins, felines, mink, ferrets and rabbits were all susceptible to SARS‐CoV‐2, while dogs were weakly susceptible and pigs, poultry, and tree shrews were not. In addition, virus replication in mice, mink, hamsters and ferrets resembled subclinical human infection, so these animals might serve as useful models for future studies to evaluate vaccines or antiviral agents and to study host‐pathogen interactions. Our review comprehensively summarized current evidence on SARS‐CoV‐2 infection in animals and their usefulness as models for studying vaccines and antiviral drugs. Our findings may direct future studies for vaccine development, antiviral drugs and therapeutic agents to manage SARS‐CoV‐2‐caused diseases.
【저자키워드】 COVID‐19, Vaccines, SARS‐CoV‐2, animal models, animal hosts, therapeutic agents, 【초록키워드】 Vaccine, Vaccine development, Diseases, Drug discovery, Clinical symptoms, Therapeutics, hamsters, antiviral drugs, Infection, systematic review, Transmission, animal model, virus, database, antiviral drug, SARS‐CoV‐2, Viral, outbreak, mice, animals, inoculation, ferret, viral replication, mink, Antiviral agents, Research, virus replication, age, therapeutic agent, animal hosts, therapeutic agents, hamster, respiratory, antiviral agent, natural infection, bats, interactions, disease transmission, Evidence, dose, Animal host, animal reservoirs, Science, acute respiratory syndrome, Web of Science, clinical symptom, human infection, SARS‐CoV‐2 infection, ferrets, PIGS, Science Direct, route, pangolins, article, reservoir, poultry, researcher, Direct, susceptible, initial, evaluate, involved, addition, conducted, searched, Rousettus, 【제목키워드】 systematic review, respiratory, animal reservoirs, reservoir,