Background: Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. Methods: In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. Results: The median age of the patients was 57 years (interquartile range 38–66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48–8.40) and mortality (6.25; 1.91–20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15–14.74), after adjusting for age, sex, hospitals and comorbidities. Conclusion: IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
【저자키워드】 COVID-19, coronavirus, diabetes, cohort study, hyperglycemia, impaired fasting glucose, severe acute respiratory coronavirus 2 (SARS-CoV-2), 【초록키워드】 Mortality, intensive care, mechanical ventilation, hospital, Comorbidities, Sex, risk, outcome, risk factor, Laboratory, adverse outcome, clinical, Wuhan, Patient, death, Complication, complications, age, Hospital admission, women, multicenter, information, Admission, association, Analysis, Cox regression, retrospective cohort study, interquartile range, higher risk, 95% confidence interval, increased risk, hazard ratio, treatment regimens, median age, poor prognosis, regression models, event, fasting glucose, enrolled, analyzed, collected, the patient, evaluated, receiving, hospitalized patient, diabete, Cox proportional hazard, patients with COVID-19, with COVID-19, 【제목키워드】 Complication, fasting, Impaired,