Coronavirus disease 2019 (COVID-19), which was named by the World Health Organization (WHO) in February 2020, has quickly spread to more than 200 countries around the world and was declared as a global pandemic in March 2020. The severity of the disease makes it more prone to severe symptoms and higher mortality rates in patients, especially those who are with comorbidities, including high blood pressure, cardiovascular disease, obesity, and diabetes, increases the concern over the consequences of this pandemic. However, initial reports do not clearly describe whether diabetes itself or associated comorbidities or treatment strategies contribute to the severe prognosis of COVID-19 infections. Various clinical trials are being conducted on glucose-lowering agents but to date, there is no standard treatment protocol approved for COVID-19 cases with pre-existing diabetes. This review is aimed to decipher the potential risk factors of COVID-19 involved from existing evidence. Identification of a novel therapeutic strategy could be beneficial for combating SARS-CoV-2, which might be dreadful to debilitating people who have diabetes.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, Diabetes Mellitus, glycemic control, 【초록키워드】 Coronavirus disease 2019, clinical trial, pandemic, protocol, Prognosis, obesity, severity, Comorbidities, Comorbidity, cardiovascular disease, diabetes, global pandemic, WHO, mortality rate, patients, therapeutic strategy, Evidence, blood pressure, treatment strategy, identification, World Health Organization, Factor, standard treatment, COVID-19 case, COVID-19 infections, potential risk, country, consequence, combating, initial, spread to, involved, the disease, approved, conducted, increase, contribute, diabete, severe symptom, 【제목키워드】 Strategy,