Objective To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19. Design Retrospective, observational cohort study. Methods We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes. Results Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients. Conclusion In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
【저자키워드】 COVID-19, Mortality, obesity, complications, overweight, 【초록키워드】 Acute kidney injury, outcome, outcomes, Probability, Clinical course, Patient, women, multicenter, patients, in-hospital mortality, association, acute respiratory distress, hospitalized COVID-19 patient, retrospective, Analysis, malignancy, Hospital stay, during admission, Observational cohort study, hospitalized COVID-19 patients, recipients, in-hospital mortality rate, multivariate logistic regression, obese, syndrome, increased mortality, acute kidney failure, organ, objective, Result, performed, evaluate, condition, groups, Length, patients hospitalized, with COVID-19, 【제목키워드】 respiratory, Increased,