Aim: In order to curb the transmission of SARS-CoV-2, nation-wide travel restrictions at different levels were implemented in different countries. Country-specific mutational profile may exist and have an impact on vaccine efficacy. Materials & methods: We identified nonsynonymous mutations in approximately 215,000 SARS-CoV-2 sequences during the 1st year of the pandemic in 35 countries. Mutational profiles on a bimonthly basis were traced over time. We also examined the mutations that overlapped with the spike protein vaccine epitopes. Results: Several new mutations emerged over time and were dominating in specific countries. Many nonsynonymous mutations were within multiple spike protein epitopes that might impact the vaccine efficacy. Conclusion: Our study advocates requirement of active monitoring of country-specific mutations and vaccine efficacies in respective countries.
【저자키워드】 SARS-CoV-2, spike glycoprotein, vaccine efficacy, Epitopes, country-specific frequent mutation, international travel restrictions, 【초록키워드】 Efficacy, Vaccine, pandemic, Mutation, Spike protein, Travel, epitope, profile, SARS-CoV-2 sequence, material, transmission of SARS-CoV-2, nonsynonymous mutation, examined, the spike protein, the vaccine, overlapped, 【제목키워드】 Efficacy, Vaccine, Variation, Temporal,