Aim: The present study was performed to determine the inhibitory interaction of fever-relieving medicines with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) essential proteins. Materials & methods: Structure-based drug repositioning was performed using PYRX 0.9 and these drugs were directed toward the predicted active site of SARS-CoV-2 spike glycoprotein receptor-binding domain, main protease and RNA-dependent RNA polymerase. Results: Results showed that acetaminophen and naproxen have considerable inhibitory activity and show a high affinity for active residues of these proteins. The prediction of activity spectra for substances (PASS) studies showed that these drugs are anti-inflammatory, antiviral and immunostimulant. Conclusion : Hence, it is proven that these drugs have antiviral activity against SARS-CoV-2 and can stimulate the immune and anti-inflammatory response against this disease.
【저자키워드】 drug repositioning, antiviral activity, Nonsteroidal anti-inflammatory drugs, naproxen, acetaminophen, Novel coronavirus-19, prediction of activity spectra for substances, 【초록키워드】 SARS-CoV-2, Anti-inflammatory, Antiviral, Proteins, drug, protease, immune, Medicine, SARS-CoV-2 spike glycoprotein, RNA-dependent RNA polymerase, disease, Coronavirus-2, Interaction, acute respiratory syndrome, residue, domain, high affinity, material, inhibitory activity, anti-inflammatory response, inhibitory, immunostimulant, Result, predicted, was performed, determine, stimulate, 【제목키워드】 in silico, Medicine,