Aim: December 2019 witnessed the emergence of a worldwide outbreak of a novel strain of coronavirus (CoV) termed SARS-CoV-2. Several preventive strategies are being developed, such as vaccines, to stop the spread of infection. Materials & methods: A comprehensive immunoinformatics approach was used to map conserved peptide sequences on the receptor binding domain of SARS-CoV-2 for their B-cell, T-helper & T-cytotoxic cell epitope profiles. Results & conclusion: The antigenic B-cell epitopes were LFRKSN and SYGFQPT. Among T-cell epitopes, CVADYSVLY and FTNVYADSF exhibited affinity for MHC class I, while YRLFRKSNL and VYAWNRKRI exhibited affinity for of MHC class II alleles. The overlapping epitope between B- and T-cells was YRLFRKSNL. The deployment of these epitopes in potential vaccine development against COVID-19 may help in slowing down the SARS-CoV-2 spread.
【저자키워드】 COVID-19, Coronaviruses, epitope mapping, human ACE2 receptor, 【초록키워드】 SARS-CoV-2, Vaccine development, coronavirus, Vaccines, Infection, alleles, peptide, Receptor binding domain, Spread, outbreak, immunoinformatics, B-cell epitope, T-cell epitopes, epitope, MHC, B-cell, overlapping, antigenic, sequence, help, profiles, material, approach, Cell, Result, was used, conserved, exhibited, B- and T-cell, the SARS-CoV-2, 【제목키워드】 immunoinformatics, SARS Coronavirus, the receptor-binding domain, Scouting,