The pandemic SARS coronavirus 2 utilizes efficient mechanisms to establish infection and evade the immune system. Established infection leads to severe inflammation in susceptible patients, the main hallmark of progression to severe coronavirus disease (COVID-19). Knowledge of the mechanisms of disease has expanded rapidly. As inflammation emerges as the central pathophysiological feature in COVID-19, elucidating how the immune system, lungs and gut communicate and interact with microbial components of the ecological niches that conform the human microbiome will shed light on how inflammation and disease progression are promoted. Studying the microbiome in COVID-19 could allow scientists to identify novel approaches to prevent severe inflammation by targeting components of the human microbiome. Innovation in the aforementioned is needed to combat this pandemic.
【저자키워드】 COVID-19, immunology, SARS-CoV-2, Inflammation, pandemic, Infectious diseases, miRNA, Microbiome, emerging diseases, microbe–host interaction, 【초록키워드】 Infection, progression, immune system, Disease progression, SARS Coronavirus, disease, mechanism, Innovation, Gut, microbial, ecological niche, severe coronavirus disease, hallmark, component, severe inflammation, susceptible patients, approach, Prevent, identify, evade, promoted, pathophysiological, 【제목키워드】 Infection,