Clinical presentations of COVID-19 exhibit a relative variation that might have roots in various circumstances. The initial infectious dose is a decisive factor in determining the fate of some viral and bacterial infections. Regarding the importance of inflammation and immunopathogenesis in the progression of COVID-19, the initial infectious dose of severe acute respiratory syndrome coronavirus 2 might have an impact on the initial inflammation and therefore the incubation period of the disease. A quick progression to severe disease might decrease the chance for successful therapy. Therefore, more release of danger-associated molecular patterns and more cytokine responses are expectable in the case of higher infectious doses. Herein we discuss the impact of initial infectious dose in the pathogenesis of similar infections such as MERS and influenza.
【저자키워드】 SARS-CoV-2, Cytokine storm, Viral load, Incubation period, initial infectious dose, 【초록키워드】 COVID-19, Inflammation, coronavirus, therapy, Pathogenesis, Influenza, Variation, Infection, progression, MERS, clinical, Immunopathogenesis, Bacterial infections, cytokine response, severe disease, infectious dose, acute respiratory syndrome, doses, decrease, initial, the disease, danger-associated molecular pattern, 【제목키워드】 severity, infectious dose, initial,