Aim: To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. Materials & methods: The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. Results: A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. Conclusion: COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset. Lay abstract This study aimed to detect the levels of antibodies made by the body in response to COVID-19, 8 months after infection. We reviewed the characteristics of 54 patients with a history COVID-19 to find factors that may influence antibody levels. The results showed that 8 months after infection, almost all the patients had sufficient antibody levels to protect them from another episode of COVID-19 and that antibody levels were especially well maintained in those with a history of severe COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, IgM, antibody, 【초록키워드】 severe COVID-19, severity, disease severity, Infection, C-reactive protein, RNA, Characteristics, protective immunity, clinical, Patient, predictor, chemiluminescence, Analysis, COVID-19 patient, Multiple linear regression, symptom onset, Factor, Abstract, IgG levels, material, positive, specific IgM, PROTECT, enrolled, analyzed, was used, detect, collected, the patient, determine, retained, IgG level, independent predictor, patients with COVID-19, 【제목키워드】 detection, anti-SARS-CoV-2 antibody, predictor, COVID-19 patient, symptom onset,