Background: Variations in the viral receptor human angiotensin-converting enzyme 2 (ACE2) may specify the susceptibility of a certain population to severe acute respiratory syndrome coronavirus 2. Objective: Evaluation of the affinity of severe acute respiratory syndrome coronavirus 2 spike glycoprotein to the Iranian genetic variants of ACE2. Materials & methods: Single nucleotide polymorphisms of ACE2 among the Iranian population were collected from the Iranome database. Missense mutations in the N-terminal peptidase domain were selected for in silico analysis. Results: 17 missense single nucleotide polymorphisms were found at ACE2. Viral glycoprotein had the lowest affinity to ACE2 mutant V485L. Discussion: The V485L variant of ACE2 could be a natural resistance mutation among the Iranian population. In addition, variant S331F can increase slightly the susceptibility to infection with the virus.
【저자키워드】 SARS-CoV-2, molecular docking, SARS-CoV-2 spike glycoprotein, Human angiotensin-converting enzyme 2, natural resistance variant, 【초록키워드】 ACE2, coronavirus, Mutation, susceptibility, variant, Infection, virus, database, Single nucleotide polymorphism, glycoprotein, Genetic variant, mutant, receptor, in silico analysis, nucleotide, acute respiratory syndrome, domain, human Angiotensin-converting enzyme, material, lowest, selected, collected, addition, N-terminal peptidase, 【제목키워드】 coronavirus, variant, Infection, acute respiratory syndrome, enzyme,